SERUM FREE LIGHT CHAIN ANALYSIS

Barbara Maniglia

International Marketing Manager - Freelite™ & Hevylite™



Introducing Wikilite.com



Wikilite.com is a new online educational resource on serum free light chain Freelite and heavy chain/light chain Hevylite analysis. Similar in content to the 5th Edition book entitled "Serum free light chain analysis (plus Hevylite)", the web pages will be continuously reviewed and updated with new publications.



Publication review – keep up to date with recent publications



MGUS

A monoclonal gammopathy precedes multiple myeloma in most patients. Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM. Blood 2009;113:5418-22


Monoclonal gammopathy of undetermined significance (MGUS) precedes Multiple Myeloma: a prospective study.

Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes RB, et al. Blood 2009;113:5412-7



In the same edition of Blood, Weiss and Landgren both report analyses examining the evolution of MGUS into multiple myeloma (MM)… more



Renal

Treatment of acute renal failure secondary to multiple myeloma with
chemotherapy and extended high cut-off hemodialysis.

Hutchison CA, Bradwell AR, Cook M, Basnayake K, Basu S, Harding S, et al. Clin J Am Soc Nephrol 2009;4:745-54 - Order: MKG516



This prospective pilot study assessed the combination of standard chemotherapy with extended haemodialysis using a high cut-off dialyser (HCO-HD) on serum FLC
concentrations and renal recovery in 19 patients with biopsy-proven cast
nephropathy and dialysis-dependent acute renal failure… more



Are renal reference intervals required when screening for plasma cell
disorders with serum free light chains and serum protein electrophoresis?

Abadie, J.M., K.H. van Hoeven, and J.M. Wells, Am J Clin Pathol, 2009. 131(2): p. 166-71.



A modified renal reference range for the FLC κ/λ ratio (0.37-3.1) was proposed for patients with renal impairment (Hutchison et al. 2008). Abadie et al. evaluated this range when screening for plasma cell disorders… more



Screening

Utility of serum free light chain analysis when screening for
lymphoproliferative disorders.

Robson, E.J.D., et al., Lab Med, 2009. 40(6): p. 325-329.



Robson et al. examined the utility of screening for lymphoproliferative disorders
using a combination of serum protein electrophoresis (SPE) and serum FLC tests. Of 653 serum samples, serum FLC analyses significantly contributed to diagnosis in seven patients… more



Inaccuracies in 24-hour urine testing for monoclonal gammopathies.

Siegel, D.S., et al., Lab Med, 2009. 40(6): p. 341-344.



Siegel et al. examine the relative merit of monitoring patients using serum and urine tests… more



Amyloidosis

Identification of amyloidogenic light chains requires the combination of
serum-free light chain assay with immunofixation of serum and urine.

Palladini, G., et al., Clin Chem, 2009. 55(3): p. 499-504.



The authors analysed the diagnostic sensitivity of serum/urine IFE and the serum FLC assay in 121 AL amyloidosis patients… more